| Date | Location | Result | |
| 03/09/22 | Fort Myers, Fla. (Alico Arena) | #20 FGCU 82, Stetson 67 | Box score |
| 03/06/22 | Florence, Ala. (Flowers Hall) | Stetson 64, North Alabama 53 | Box score |
| 03/02/22 | DeLand, FL | Stetson 81, Bellarmine 53 | Box score |
| 02/26/22 | DeLand, Fla. (Edmunds Center) | Stetson 59, North Florida 47 | Box score |
| 02/24/22 | Kennesaw, Ga. (Convocation Center) | Stetson 75, Kennesaw State 64 | Box score |
| 02/19/22 | Lynchburg, Va. (Liberty Arena) | Liberty 65, Stetson 53 | Box score |
| 02/17/22 | DeLand, Fla. (Edmunds Center) | Stetson 65, Jacksonville 55 | Box score |
| 02/12/22 | Fort Myers, Fla. (Alico Arena) | Stetson 58, #20 FGCU 55 | Box score |
| 02/09/22 | DeLand, Fla. (Edmunds Center) | Stetson 70, Jacksonville State 66 | Box score |
| 02/05/22 | Conway, Ark. (Farris Center) | Stetson 63, Central Arkansas 45 | Box score |
| 02/03/22 | Nashville, Tenn. (Allen Arena) | Stetson 61, Lipscomb 50 | Box score |
| 01/29/22 | DeLand, Fla. (Edmunds Center) | Stetson 70, Eastern Kentucky 52 | Box score |
| 01/27/22 | DeLand, Fla. (Edmunds Center) | Stetson 64, Bellarmine 53 | Box score |
| 01/22/22 | Florence, Ala. (Flowers Hall) | Stetson 75, North Alabama 43 | Box score |
| 01/19/22 | DeLand, Fla. (Edmunds Center) | #21 FGCU 78, Stetson 41 | Box score |
| 01/15/22 | DeLand, Fla. (Edmunds Center) | Kennesaw State 61, Stetson 60 | Box score |
| 01/12/22 | Jacksonville, Fla. (Swisher Gym) | Jacksonville 63, Stetson 51 | Box score |
| 01/08/22 | Jacksonville, Fla. (UNF Arena) | Stetson 73, North Florida 62 | Box score |
| 01/05/22 | DeLand, Fla. (Edmunds Center) | Liberty 65, Stetson 49 | Box score |
| 12/19/21 | DeLand, Fla. (Edmunds Center) | Tennessee State 60, Stetson 56 | Box score |
| 12/17/21 | DeLand, Fla. (Edmunds Center) | Stetson 64, VCU 58 | Box score |
| 12/15/21 | Tampa, Fla. (Yuengling Center) | #16 USF 69, Stetson 50 | Box score |
| 12/12/21 | Worcester, Mass. (Hart Center) | Holy Cross 65, Stetson 50 | Box score |
| 12/06/21 | DeLand, Fla. (Edmunds Center) | Stetson 91, Florida National 35 | Box score |
| 12/04/21 | Greenville, S.C. (Timmons Arena) | Stetson 67, Furman 58 | Box score |
| 11/28/21 | Katy, Texas (Merrell Center) | Old Dominion 61, Stetson 51 | Box score |
| 11/27/21 | Katy, Texas (Merrell Center) | Stetson 51, Saint Joseph's 48 | Box score |
| 11/26/21 | Katy, Texas (Merrell Center) | Stetson 70, Louisiana Monroe 37 | Box score |
| 11/20/21 | Lake Buena Vista, Fla. (HP Fieldhouse) | Stetson 57, Manhattan 55 | Box score |
| 11/19/21 | Lake Buena Vista, Fla. (HP Fieldhouse) | Fairfield 59, Stetson 50 | Box score |
| 11/14/21 | Coral Gables, Fla. (Watsco Center) | Miami (Fla.) 54, Stetson 39 | Box score |
| 11/09/21 | DeLand, Fla. -- Edmunds Center | Stetson 127, Johnson (Fla.) 36 | Box score |